UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability.
Mitchell JE, Lund MM, Starmer J, Ge K, Magnuson T, Shpargel KB and Whitmire JK.
Cell Rep. 2021 Apr 13;35(2):108966. doi: 10.1016/j.celrep.2021.108966.

 

Shpargel KB, Mangini CL, Xie G, Ge K, Magnuson T. The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology. Development. 2020 Jul 17;147(21):dev187997.

 

Kalisz M, Bernardo E, Beucher A, Maestro MA, Del Pozo N, Millán I, Haeberle L, Schlensog M, Safi SA, Knoefel WT, Grau V, de Vas M, Shpargel KB, Vaquero E, Magnuson T, Ortega S, Esposito I, Real FX, Ferrer J. HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer. EMBO J. 2020 May 4;39(9):e102808.

 

Wijayatunge R, Liu F, Shpargel KB, Wayne NJ, Chan U, Valeria-Boua J, Magnuson T, West AE. The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons. Molecular and Cellular Neuroscience. 2017 Dec 15; pii: S1044-7431(17)30243-9.

 

Shpargel KB, Starmer J, Chaochen Wang, Kai Ge, Magnuson T. UTX guided neural crest function underlies clinical features of Kabuki Syndrome. Proceedings of the National Academy of Sciences. 2017 Oct 24;114(43):E9046-E9055.

 

Cook KD and Shpargel KB, Starmer J, Whitfield-Larry F, Conley B, Allard DE, Rager JE, Fry RC, Davenport ML, Magnuson T, Whitmire JK, Su MA. T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX. Immunity. 2015 Oct 20;43(4):703-14.

 

Shi X, Zhang Z, Zhan X, Cao M, Satoh T, Akira S, Shpargel K, Magnuson T, Li Q, Wang R, Wang C, Ge K, Wu J. An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth. Nature Communications. 2014 Nov 5;5:5425.

 

Shpargel KB, Starmer J, Yee D, Pohlers M, Magnuson T. KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development. PLoS Genetics. 2014 Aug 7;10(8):e1004507.

 

Shpargel KB, Sengoku T, Yokoyama S, Magnuson T. UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genetics. 2012 Sep;8(9):e1002964.

 

Chen Z, Jalabi W, Shpargel KB, Farabaugh KT, Dutta R, Yin X, Kidd GJ, Bergmann CC, Stohlman SA, Trapp BD. Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. Journal of Neuroscience. 2012 Aug 22;32(34):11706-15.

 

Kurima K, Hertzano R, Gavrilova O, Monahan K, Shpargel KB, Nadaraja G, Kawashima Y, Lee KY, Ito T, Higashi Y, Eisenman DJ, Strome SE, Griffith AJ. A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice. PLoS Genetics. 2011 Sep;7(9):e1002307.

 

Shpargel KB, Praveen K, Rajendra TK, Matera AG. Gemin3 is an essential gene required for larval motor function and pupation in Drosophila. Molecular Biology of the Cell. 2009 Jan;20(1):90-101.

 

Shpargel KB, Jalabi W, Jin Y, Dadabayev A, Penn MS, Trapp BD. Preconditioning paradigms and pathways in the brain. Cleveland Clinic Journal of Medicine. 2008 Mar;75 Suppl 2:S77-82.

 

Rajendra TK, Gonsalvez GB, Walker MP, Shpargel KB, Salz HK, Matera AG. A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle. Journal of Cell Biology. 2007 Mar 12;176(6):831-41.

 

Matera AG, Shpargel KB. Pumping RNA: nuclear bodybuilding along the RNP pipeline. Current Opinion in Cell Biology. 2006 Jun;18(3):317-24.

 

Shpargel KB, Matera AG. Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins. Proceedings of the National Academy of Sciences. 2005 Nov 29;102(48):17372-7.

 

Xu H, Pillai RS, Azzouz TN, Shpargel KB, Kambach C, Hebert MD, Schümperli D, Matera AG. The C-terminal domain of coilin interacts with Sm proteins and U snRNPs. Chromosoma. 2005 Aug;114(3):155-66.

 

Shpargel KB, Makishima T, Griffith AJ. Col11a1 and Col11a2 mRNA expression in the developing mouse cochlea: implications for the correlation of hearing loss phenotype with mutant type XI collagen genotype. Acta Otolaryngologica. 2004 Apr;124(3):242-8.

 

Dundr M, Hebert MD, Karpova TS, Stanek D, Xu H, Shpargel KB, Meier UT, Neugebauer KM, Matera AG, Misteli T. In vivo kinetics of Cajal body components. Journal of Cell Biology. 2004 Mar 15;164(6):831-42.

 

Vandenbergh DJ, Heron K, Peterson R, Shpargel KB, Woodroffe A, Blizard DA, McClearn GE, Vogler GP. Simple tests to detect errors in high-throughput genotype data in the molecular laboratory. Journal of Biomolecular Techniques. 2003 Mar;14(1):9-16.

 

Shpargel KB, Ospina JK, Tucker KE, Matera AG, Hebert MD. Control of Cajal body number is mediated by the coilin C-terminus. Journal of Cell Science. 2003 Jan 15;116(Pt 2):303-12.

 

Hebert MD, Shpargel KB, Ospina JK, Tucker KE, Matera AG. Coilin methylation regulates nuclear body formation. Developmental Cell. 2002 Sep;3(3):329-37.

 

Hebert MD, Szymczyk PW, Shpargel KB, Matera AG. Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein. Genes and Development. 2001 Oct 15;15(20):2720-9.

 

Tucker KE, Berciano MT, Jacobs EY, LePage DF, Shpargel KB, Rossire JJ, Chan EK, Lafarga M, Conlon RA, Matera AG. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. Journal of Cell Biology. 2001 Jul 23;154(2):293-307.

 

McGuirt WT, Prasad SD, Griffith AJ, Kunst HP, Green GE, Shpargel KB, Runge C, Huybrechts C, Mueller RF, Lynch E, King MC, Brunner HG, Cremers CW, Takanosu M, Li SW, Arita M, Mayne R, Prockop DJ, Van Camp G, Smith RJ. Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13). Nature Genetics. 1999 Dec;23(4):413-9.